Evidence
Same model and position · retrieved passages supplied · first output
In observational studies with time-varying treatments, marginal structural models (MSMs) were developed to estimate the joint causal effects of a time-varying treatment in the presence of time-varying confounding, relying on a sequential randomization assumption for identification.
Passages supplied to the Evidence version
A Simple Weighted Approach for Instrumental Variable Estimation of Marginal Structural Mean Models ↗
Robins [ 13 , 14 , 15 ] introduced marginal structural models (MSMs), a class of counterfactual models that encode the joint causal effects of time-varying treatment in the presence of time-varying confounding. For identification, Robins relied on a sequential randomization assumption (SRA), which r…
Read full passage excerpt
Robins [ 13 , 14 , 15 ] introduced marginal structural models (MSMs), a class of counterfactual models that encode the joint causal effects of time-varying treatment in the presence of time-varying confounding. For identification, Robins relied on a sequential randomization assumption (SRA), which rules out unmeasured confounding of the time-varying treatment. MSMs have since become the standard analytic approach to evaluate causal effects in time-varying epidemiological studies [ 7 , 10 , 3 , 4 , 17 ] . However, SRA may be hard to justify in many such settings, and unmeasured confounding bias may invalidate causal claims inferred by the approach. In the case of a point treatment, a large literature in causal inference has developed over the years on the instrumental variable method aiming to address unmeasured confounding [ 8 , 2 , 12 ] .