…n criteria which can lead to a trial sample that differs markedly from the population potentially eligible for the treatment. Therefore, the findings from RCTs can lack generalizability to a target population of interest. This concern is related to the aim of external validity , central in medical research ( Concato et al.,, 2000 ; Rothwell,, 2005 ; Green and Glasgow,, 2006 ; Frieden,, 2017 ) policy research ( Martel Garcia and Wantchekon,, 2010 ; Deaton and Cartwright,, 2018 ; Deaton et al.,, 2019 ; Jeong and Namkoong,, 2022 ) , and other fields such as advertising ( Gordon et al.,, 2019 ) .
…er assumptions such as unconfoundedness it is possible to estimate a causal treatment effect from observational data. In practice, methods such as matching, inverse propensity weighting (IPW), or augmented IPW (AIPW) are used ( Imbens and Rubin,, 2015 ) . Even when a confounder is unobserved, solutions exist at the price of additional assumptions, for example the front-door criterion ( Pearl,, 1993 ) , instrumental variables ( Angrist et al.,, 1996 ; Hernán and Robins,, 2006 ; Imbens,, 2014 ) , and sensitivity analysis ( Cornfield et al.,, 1959 ; Rosenbaum and Rubin,, 1983 ; Imbens,, 2003 ) .
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