Evidence
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involves a terminal event that precludes the occurrence of a nonterminal event, while the reverse transition remains observable.
Passages supplied to the Evidence version
Card 1 · The choice to define competing risk events as censoring events and implications for causal inference
In failure-time settings, a competing risk event is any event that makes it impossible for the event of interest to occur. For example, death from cancer is a competing event for stroke because an individual cannot have a stroke once they have died of cancer. In follow-up studies, competing events c…
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In failure-time settings, a competing risk event is any event that makes it impossible for the event of interest to occur. For example, death from cancer is a competing event for stroke because an individual cannot have a stroke once they have died of cancer. In follow-up studies, competing events cannot be prevented by design and can occur even in randomized experiments with full adherence to the assigned treatment strategies and no losses to follow-up.
Card 2 · A threshold‐free summary index of prediction accuracy for censored time to event data
Prediction performance of a risk scoring system needs to be carefully assessed before its adoption in clinical practice. Clinical preventive care often uses risk scores toscreenasymptomatic population. The primary clinical interest is to predict the risk of having an event by a prespecifiedfuturetim…
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Prediction performance of a risk scoring system needs to be carefully assessed before its adoption in clinical practice. Clinical preventive care often uses risk scores toscreenasymptomatic population. The primary clinical interest is to predict the risk of having an event by a prespecifiedfuturetimet0. Accuracy measures such as positive predictive values have been recommended for evaluating the predictive performance. However, for commonly used continuous or ordinal risk score systems, these measures require a subjective cutoff threshold value that dichotomizes the risk scores. The need for a cutoff value created barriers for practitioners and researchers. In this paper, we propose a threshold‐free summary index of positive predictive values that accommodates time‐dependent event status and competing risks. We develop a nonparametric estimator and provide an inference procedure for comparing this summary measure between 2 risk scores for censored time to event data. We conduct a simul …
Card 3 · Siamese Survival Analysis with Competing Risks
Survival analysis in the presence of multiple possible adverse events, i.e., competing risks, is a pervasive problem in many industries (healthcare, finance, etc.). Since only one event is typically observed, the incidence of an event of interest is often obscured by other related competing events.…
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Survival analysis in the presence of multiple possible adverse events, i.e., competing risks, is a pervasive problem in many industries (healthcare, finance, etc.). Since only one event is typically observed, the incidence of an event of interest is often obscured by other related competing events. This nonidentifiability, or inability to estimate true cause-specific survival curves from empirical data, further complicates competing risk survival analysis. We introduce Siamese Survival Prognosis Network (SSPN), a novel deep learning architecture for estimating personalized risk scores in the presence of competing risks. SSPN circumvents the nonidentifiability problem by avoiding the estimation of cause-specific survival curves and instead determines pairwise concordant time-dependent risks, where longer event times are assigned lower risks. Furthermore, SSPN is able to directly optimize an approximation to the C-discrimination index, rather than relying on well-known metrics which are …
Card 4 · Estimating causal effects in the presence of competing events using regression standardisation with the Stata command standsurv
When interested in a time-to-event outcome, competing events that prevent the occurrence of the event of interest may be present. In the presence of competing events, various statistical estimands have been suggested for defining the causal effect of treatment on the event of interest. Depending on…
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When interested in a time-to-event outcome, competing events that prevent the occurrence of the event of interest may be present. In the presence of competing events, various statistical estimands have been suggested for defining the causal effect of treatment on the event of interest. Depending on the estimand, the competing events are either accommodated or eliminated, resulting in causal effects with different interpretation. The former approach captures the total effect of treatment on the event of interest while the latter approach captures the direct effect of treatment on the event of interest that is not mediated by the competing event. Separable effects have also been defined for settings where the treatment effect can be partitioned into its effect on the event of interest and its effect on the competing event through different causal pathways. We outline various causal effects that may be of interest in the presence of competing events, including total, direct and separable …
Card 5 · Competing risks regression for clustered survival data via the marginal additive subdistribution hazards model
A population‐averaged additive subdistribution hazards model is proposed to assess the marginal effects of covariates on the cumulative incidence function and to analyze correlated failure time data subject to competing risks. This approach extends the population‐averaged additive hazards model by a…
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A population‐averaged additive subdistribution hazards model is proposed to assess the marginal effects of covariates on the cumulative incidence function and to analyze correlated failure time data subject to competing risks. This approach extends the population‐averaged additive hazards model by accommodating potentially dependent censoring due to competing events other than the event of interest. Assuming an independent working correlation structure, an estimating equations approach is outlined to estimate the regression coefficients and a new sandwich variance estimator is proposed. The proposed sandwich variance estimator accounts for both the correlations between failure times and between the censoring times, and is robust to misspecification of the unknown dependency structure within each cluster. We further develop goodness‐of‐fit tests to assess the adequacy of the additive structure of the subdistribution hazards for the overall model and each covariate. Simulation studies ar …
Model-reported card use
Card 1 · terminology
Affected output: a terminal event that precludes the occurrence of a nonterminal event
Model explanation: Row 1 supplies the field-native definition of an event that makes another event impossible, which licenses phrasing the terminal event as precluding the nonterminal event.