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Biological systems are characterized by densely interconnected entities, with genes, proteins, and metabolites participating in multiple overlapping interactions that give rise to highly connected hub nodes. Such structural properties distinguish biological networks from the sparser, more uniformly connected graphs typically assumed in general-purpose link prediction benchmarks.
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Neural Multi-Hop Reasoning With Logical Rules on Biomedical Knowledge Graphs
From a machine learning perspective, reasoning on biomedical KGs presents new challenges for existing approaches due to the unique structural characteristics of the KGs. One challenge arises from the highly coupled nature of entities in biological systems that leads to many high-degree entities that…
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From a machine learning perspective, reasoning on biomedical KGs presents new challenges for existing approaches due to the unique structural characteristics of the KGs. One challenge arises from the highly coupled nature of entities in biological systems that leads to many high-degree entities that are themselves densely linked. For example, as illustrated in Figure 1(a) , genes interact abundantly among themselves.