Bridging from single to collective cell migration: A review of models and links to experiments

Output A is fully grounded in the draft. It continues the contrast between medically-oriented computational research (cancer, liver toxicity, lung morphogenesis) and basic scientific computational research on multiscale cell biology, noting this imbalance and suggesting a more balanced approach. Every element traces to the draft's explicit claims about funding motivations and the emerging state of basic scientific computational research. Output B introduces unsupported claims: (1) 'stochastic descriptions of individual cell motion' - the source mentions 'stochastic processes' and the Smoluchowski equation but not individual cell motion in migration; (2) 'continuum and agent-based treatments of collective migration' - not mentioned in draft or source; (3) 'parameters that govern single-cell behavior are not always the ones that determine tissue-level patterns' - a substantive mechanistic claim about parameter relationships across scales with no support in the provided materials; (4) 'Bridging these scales remains a central challenge' - evaluative claim not grounded in the draft. The draft mentions 'multiscale cell biology modeling' as an emerging field but does not describe what scales are bridged, what methods are used, or what challenges exist. Output B reads as generic computational biology commentary rather than continuation of this specific manuscript's argument about funding imbalances.